clinicobiochemical approach to etiogenesis of immunocompromization in patients with chronic renal failure

ABSTRACT

Immunologic disturbance of T and B lymphocytes was reported in uremic patients. An approach to the etiology of such immunocompromization was made by determination of plasma adenosine deaminase [ADA], 5'-nucleotidase, IgG, zinc and vitamin B6 together with erythrocyte adenosine-5-phosphate deaminase [AMP], adenosine deaminase [ADA] and 5'-nucleotidase in 30 uremic patients before and after dialysis. The results were compared with their counterparts in 30 healthy controls which were age matched to patients. The results clarified that the immune disturbances in patients with uremia were multifactorial resulting from decreased ADA together with nutritional deficiency of zinc and vitamin B6. Therefore, supplement of these patients with deficient nutrients should be considered