Effect of three rubber elastomers on the stability of amikacin and kanamycin in parenteral solutions

Three rubber elastomers [natural, bromobutyl and their blend] were prepared, exhibited good physicomechanical and chemical properties and suitable for use as parenteral stoppers. The effect of these elastomers on the stability of amikacin and kanamycin in solutions was investigated. The three elastomers were found to augment the loss of each antibiotic upon storage. The loss increased with time. The effect was more pronounced at 60C rather than at 25C. Bromobutyl elastomer showed the least determinative effect towards the antibiotic potency relative to the reference elastomer, as it exhibited the lowest sorption characteristics than the natural elastomer. Leached materials from rubber elastomers slightly affected the loss of antibiotics from solutions