effect of gentamicin on p-aminohippurate uptake by rat renal cortical slices

ABSTRACT

The mechanism of P-aminohippurate [PAH] uptake by cortical slices of rat kidney was investigated. The uptake of PAH was significantly greater in rats injected with gentamicin for 4 days than in the control group. The uptake of PAH by renal cortical slices was not affected by adding gentamicin to the incubation medium. The data suggest that gentamicin specifically stimulates the organic acid transport system and that this effect may represent an early functional correlate of gentamicin nephrotoxicity