Helicobacter pylori in various gastrointestinal diseases

ABSTRACT

Two hundred and ten patients with different upper gastrointestinal diseases as well as celiac disease and liver cirrhosis were studied to determine the frequency of gastric irthabitation by Heicobacter pyloti [HP]. The study also assessed the effect of a combination of sucralfate, Amoxiycillin And Metronidazole on eradication of HP, relief of symptoms and healing of ulcers and duodenitis. Per endoscopic antral biopsies were taken from all patients for rapid urease test [RUT]. Except for patients with liver cirrhosis, a second biopsy was also taken for histopathology and identification of the organism in the stained specimens RUT was positive for HP in 88.3% of duodenal ulceration, 72.7% of duodenitis, 66.7% of gastric atrophy, 61.9% of cirrhosis, 60% of gastric ulcer, 59.25% of celiac disease and in 57% of non-ulcer dyspepsia [NUD] patients. HP was identified histologically in 73.3% of duodenal ulceration, 72.7% of duodenitis, 66.7% of gastric atrophy, 60% of gastric ulcer and 55.5% of non-ulcer dyspepsia. After triple therapy RUT became negative in 47%, 573% and 85.7% of patients with duodenal ulcer, non-ulcer dyspepsia and duodenitis respectively. The overall healing rates were 63.3% in duodenal ulceration and 100% in duodenitis. This study rests that despite the non-specific correlation of HP with celiac disease and liver cirrhosis, there is a strong association with both ulcer and non-ulcer patients; the triple therapy proved to be effective for both clinical improvement and endoscopic resolution of the lesions