Antithrombotic activity of clove oil
JPMA-Journal of Pakistan Medical Association. 1994; 44 (5): 112-115
en Inglés
| IMEMR
| ID: emr-33091
ABSTRACT
Clove oil inhibited human platelet aggregation induced by arachidonic acid [AA], platelet-activating factor [PAF] or collagen. Clove oil was a more effective inhibitor for aggregation induced by AA and PAF [IC[50] 4 and 6 micro M respectively] than collagen [IC[50] 132 micro M]. The in vivo experiments in rabbits showed that clove oil [50-100mg/kg] afforded 100% protection against PAF [11mg/kg, i.v.] and 70% protection against AA [2.0 mg/kg, i.v.]- induced thrombosis and shock due to pulmonary platelet thrombosis. It also inhibited thromboxane-A[2] and 12-HETE production by human platelets incubated with [C[14]] AA. These results are indicative that clove oil is inhibitory of platelet aggregation and thromboxane synthesis and may act as anti- thrombotic agent
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Agregación Plaquetaria
/
Antiinflamatorios no Esteroideos
Límite:
Animales
Idioma:
Inglés
Revista:
J. Pak. Med. Assoc.
Año:
1994
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