Effect of some commercial antacids and tea drink on the bioavaiblilty of frusemide
Mansoura Journal of Pharmaceutical Sciences. 1994; 10 (1): 64-77
en Inglés
| IMEMR
| ID: emr-33349
ABSTRACT
The bioavailability of frusemide [FR] after oral administration of FR alone or FR with antacids or FR with antacids and tea drink was investigated using rabbits. The urinary excretion rate was monitored and drug concentrations were compared. The results revealed that the drug bioavailability was markedly reduced in the presence of the selected antacids, viz. Neogelco and Simeco suspensions, and Stomaclin powder. A significant reduction was recorded in both the total cumulative amount excreted over 24 h [P <0.05] and the excretion rate of the drug [P <0.01]. Tea drink was found to have an influence on FR absorption, if taken concurrently with the tested antacids. With Stomaclin powder, tea drink significantly [P <0.01] increased the biological availability of FR compared with that obtained with antacid alone, while such effect in case of Neogelco suspension was insignificant [P >0.05]. With Simeco suspension, however, tea drink significantly [P <0.01] reduced the biological availability of FR
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Disponibilidad Biológica
/
Interacciones Farmacológicas
/
Furosemida
/
Antiácidos
Idioma:
Inglés
Revista:
Mansoura J. Pharm. Sci.
Año:
1994
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