effect of azathioprine on the pulp tissue of rat offsprings

ABSTRACT

12 adult pregnant female albino rats were used in this study. They were divided into two groups Control group included 4 female pregnant rats, experimental group included 8 female pregnant rats. They were given 0.6 mg/day of azathioprine orally, from the first week of pregnancy until delivery. After parturition, the drug was stopped at once and the offsprings were sacrificed at 7, 21 and 35 days after birth. The jaws were dissected, decalcified and prepared for routine light microscopic examination using [H and E] stain. The results obtained from the experimental group were compared with those of the control group. The results showed mild to severe dilatation of the blood vessels with some degree of inflammation in the pulp tissue. There was extravasated red bloods cells and hemorrhage in the pulp. Edematous pulp tissue with abscesses formation were also observed