Pharmacokinetics of cloxacillin in humans

Urinary excretion data were obtained after oral administration of a single dose of 250 mg of Cloxacillin in six healthy young men volunteers. The excretion rate data were fitted to single and two compartment open models and the pharmacokinetic parameters were determined. The drug showed a rapid absorption and fast distribution. The time of appearance of peak renal excretion was 45 minutes in all the volunteers. The biological half-life [47 +/- 3.6 min] and total renal recovery [31.43 +/- 2.5%] was in good agreement with the reported values. Although both the single and two compartments model fitting was not possible. One compartment model was found to be more suited as the generated data through this model bears close resemblance with the experimental data