effect of some antirheumatic drugs on the ultrastructural and histochemical pattern of guinea pig jejunal mucosa

ABSTRACT

The effect of acetyl salicylic acid, phenyl butazone and dexamethazone on the ultrastructure and histochemical pattern of guinea pig jejunal mucosa was studied. Electronmicroscopic examination showed atrophy of the microvilli and diminution of the cellular organelles. These changes were mainly manifested with acetyl salicylic acid administration. Succinic dehydrogenase, alkaline and acid phosphatases and non-specific esterase activity was studied. No changes in the activity of the non-specific esterase enzyme were detected, while diminution of the activity of the other three enzymes was more manifested with acetyl salicylic acid administration, and to a lesser extent with phenyl butazone administration. The results were discussed in the text