Liver and kidney functions in cattle vaccinated with tissue culture rinderpest vaccine

ABSTRACT

This study was conducted to determine the effect of rinderpest tissue culture vaccine on the hepatorenal functions of cross-breed Friesian calves. 8 calves [8 - 14 months of age and weighing 150 - 180 kg] were vaccinated with tissue culture rinderpest vaccine [10 4-B TCID 50/ml/calf] and blood samples were collected before vaccination and at 3, 7, 14 and 21 days post-vaccination. The results revealed that the calves became immunized against rinderpest disease where the neutralizing antibodies reached its peak [2.52 +/- 0.02 log 10/ml] by 21 days. The calves showed increase in total protein at 21 days and globulin at 14 and 21 days, while albumin was decreased at 14 and 21 days. SGOT, SGPT, bilirubin, creatinine and blood-urea-nitrogen did not change. It is concluded that the tissue culture rinderpest vaccine has no effect on liver and kidney functions and it produces a good level of immunity