Bio-pharmaceutical evaluation of tenoxicam suppositories

ABSTRACT

With the object of reducing hepatic first-pass elimination of tenoxicam, the drug was formulated in suppository form using different suppository bases. The bases used include Witepsols, Suppocires, Novatas in addition to PEGs an cacao butter. The effect of different additives, surfactants and gels, on drug suppository formulation in Witepsol H15 was also investigated. Suppositories containing tenoxicam solid dispersions were also evaluated, using PEG 4000 and 6000, PVP K25, the hydrotropes sodium benzoate and sodium salicylate, urea, lactose, sorbitol, mannitol, and the electrolytes sodium chloride, magnesium carbonate and aluminum hydroxide. The suppositories prepared were evaluated for in vitro drug release, when fresh and on storage. Selected formulae were also evaluated through tenoxicam relative bioavailability and its anti-inflammatory activity compared to indomethacin as reference drug