Tissue changes during topical cephalexin treatment of burn wounds

ABSTRACT

The value of cephalexin cream [1% and 2%] as a local measure in prevention of wound sepsis and promotion of healing was assessed histologically in an electrothermal burn. Electrical burn wounds were induced in guinea pigs using a soldering gun in order to initiate a full -thickness burn. These wounds were treated with cephalexin cream for twenty days. The wounds were described microscopically and studied microscopically on two sessions of ten days interval from the antibiotic application. The data obtained showed that cephalexin cream can modify healing of burnt tissue by shortening the time required for healing and almost preventing wound sepsis, by the production of granulation tissue with less pronounced acute inflammatory reaction and by the formation of small and less numerous blood vessels with rapid increase in collagen deposition