Aminosidine sulphate in experimental giardiasis

ABSTRACT

In this study, a locally acting drug aminosidine-sulfate [gabbroral] was used in the treatment of experimental giardiasis in a rat model under different conditions of gastric acidity which is one of the main local factors affecting the pathogenicity of the organism. The best results were obtained in the group with hyperacidity which was induced by indomethacin [indocid] with significant improvement in the pathological picture and parasitic count. While, in experimental animals with normal acidity, there was only partial eradication of the parasite. However, in the group with hypoacidity induced by cimetidine [cimetex], the drug showed no beneficial effects since most of organisms invaded the deeper layers of the intestine, escaping the local action of the drug