Superoxide dismutase, calcium, copper, ceruloplasmine levels after single and repeated exposure to halothane or isoflurane in albino rats

ABSTRACT

This study was done on 72 albino rats from both sexes. They were divided into three equal groups according to the time of exposure to the oxygen [control], isoflurane or halothane. Time of exposure was single [1 hour] or 3 or 5 exposures with 5 days rest in between. Samples were taken after 24 hours after the last exposure. Serum calcium, copper ceruloplasmine levels were estimated. Superoxide dismutase enzyme activity was also determined and showed a significant drop in the enzyme activity after both isoflurane and halothane anesthesia. The results of this study explored the potential risk of free oxygen radicals on liver cells after exposure of the rats to isoflurane or halothane anesthesia