Renal changes in experimental trichinosis [histopathological, electron microscopic and immunofluorescent study]

ABSTRACT

The study was performed using 120 white rats [80 infected with Trichinella spiralis and 40 as a control group]. Histopathology, electron microscopy, direct and indirect immunofluorescence were carried out on the proper kidney tissue preparations weekly for 20 weeks after infection. Histopathological changes were detected in the glomeruli, tubules, and stroma of the infected animals from the 6th week after infection. Transmission electron microscopy revealed ultrastructural changes in the glomeruli and tubules, coinciding with the onset of the histopathological changes. Deposits of immunoglobulins and specific Trichinella spiralis antigens were detected in the blood vessels and glomeruli from the 8th week after infection. The results were discussed and the immunopathological mechanism of tissue damages was clarified