Serum apolipoproteins in ischemic heart disease correlated with the extent and severity of CAD

ABSTRACT

Serum apolipoportein A-1 [apo A-1] and apolipoprotein B [apo B] in 42 patients [28 males and 14 females] undergoing elective coronary angiography were correlated with the number of stenosed major coronary arteries and with extent and severity of coronary artery disease [CAD]. Fasting serum levels of total cholesterol [TC], triglycerides [TG], high density lipoprotein cholesterol [HDL-C], low density lipoprotein cholesterol [LDL-C] were also correlated. Simple linear regression analysis, unpaired student t-test, and analysis of valiance [ANOVA] were used to compare the means. Twenty eight patients had CAD [group I] while, 14 subjects had angiographically normal coronaries [group II]. In group I, as a whole, the patients with 3 vessel disease [3VD] had a significantly lower level of apo A-1 than those with single vessel disease [single VD] while, the HDL-C level showed nonsignificant [NS] difference. In males with 3VD both apo A-1 and HDL-C levels were significantly lower [P <0.01, P <0.01] than in those with single VD. In group I, as a whole, significant correlations were proved between the extent and the angioscore for severity of CAD and LDL-C [P <0.05], the ratios TC/HDL-C [P <0.01] and LDL/HDL-C [P <0.01], apo A-1 [P <0.05], apo B [P <0.01] and the ratio apo B/apo A-1 [P <0.01]. HDL-C showed NS correlation