Microbial toxicity of juliflorine, julifloricine and benzene insoluble alkaloidal fraction of prosopis juliflora

ABSTRACT

Juliflorine, julifloricine and benzene insoluble alkaloidal fraction of Prosopis juliflora, which have been found to possess atimicrobial activity, were studied in vitro for microbial toxicity by Pseudomonas Fluorescens test and genotoxicity by Ames Salmonella/Microsomal mutagenicity test. In P. Fluorescens system, EC50 values were determined as 120.2 micro g/ml for juliflorine; 524.8 micro g/ml for julifloricine and 112.2 micro g/ml for benzene insoluble alkaloidal fraction. Thus the fraction is more toxic and julifloricine least - on other hand the fraction has strong antibacterial activity. None of the alkaloidal was found mutagenic up to 500 micro g per plate and hence these are noncarcinogenic