Serum lipid profile and lipoprotein [a] in patients with chronic renal failure [CRF] under different methods of therapy
Scientific Medical Journal. 1995; 7 (3): 9-24
en Inglés
| IMEMR
| ID: emr-39723
ABSTRACT
Eighty subjects [60 patients with chronic renal failure [CRF] under different method of therapy, in addition to 20 healthy normal control subjects] were included in this study. They were subdivided into the following groups. Group I included 20 normal health subjects as controls. Group II included 20 patients of CRF under conservative treatment. Group III included 20 patients of CRF under haemodialysis [HD]. Group IV included 20 patients of CRF under chronic peritoneal dialysis [CPD]. For all groups serum lipid profile was done including serum triglycerides total cholesterol, HDL-C, LDL-C, HDL-C/ LDL-C ratio, ApoA, ApoB, ApoA/ApoB ratio and Lipoprotein [a] [Lp[a]], And we get the following results:
There was a significant increase in serum triglycerides in different groups of CRF under different methods of therapy [conservative treatment, haemodialysis and chronic peritoneal dialysis] [P < 0.001 for all]. There was a significant increase in total serum cholesterol in patients with CRF under chronic peritoneal dialysis [P < 0.001], but non significant changes in the conservative treatment [P > 0.05] and haemodialysis [P > 0.05] groups. There was a significant decrease in HDL-C in all the studied groups of CRF under different methods of therapy [P< 0.001 for all]. There was a significant increase in LDL-C in CRF patients under CPD [P < 0.001, and non significant chnages in its level in the conservative treatment and HD groups [P > 0.05 for both]. There was a significant decrease in HDL - C/LDL-C ratio in all groups of CRF under different methods of therapy [conservative treatment [P < 0.001], HD [P < 0.01] and CPD [P<0.001]]. There was a significant decrease in ApoA in all groups of CRF under different methods of therapy [P < 0.001 for all]. There was a significant increase in ApoB in CPD group [P < 0.001] and non significant changes in both the conservative treatment and haemodialysis groups [P > 0.05 for both]. There was a significant decrease in ApoA /ApoB ratio in all groups of CRF under different methods of therapy [P < 0.001 for all]. There was a significant increase in serum LP [a] in all groups of CRF under different methods of therapy [P < 0.001 for all]. The level of LP [a] in both the HD and the CPD groups both before and after dialysis was non significantly changed. There was significant negative correlation between Lp [a] and both of HDL - C / LDL -C ratio [P < 0.05 for all groups] and Apo A /Apo B ratio [P < 0.05 for all groups]. There was a significant Positive correlation between serum level of Lp [a] and the duration of treatment for conservative treatment group [P < 0.05], and non significant changes in both HD and CPD groups [P > 0.05 for both]. There are changes in serum lipid profile and Lp [a] in CRF patients under different methods of therapy which share with other factors for increasing succeptibility to atherogenecity in these patients
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Diálisis Renal
/
Hiperlipidemias
/
Fallo Renal Crónico
/
Lípidos
/
Lipoproteínas
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Sci. Med. J.
Año:
1995
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