Glycosylated hemoglobin level in Saudi children with sickle cell anaemia

ABSTRACT

To evaluate the glucose-6-phosphate dehydrogenase [G6PD] status in ameliorating the disease in sickle cell paediatric patient. Design: Prospective study of patient with sickle cell anaemia with and without G6PD deficiency. Setting: Paediatric Department, Qatif Central Hospital, Saudi Arabia. Sickle cell paediatric patient. The mean HbA[1]C in patient with SS disease was 6.5 +/- 0.9%, while that in normal paediatric patient was 6.3 +/- 1.5% [P value > 0.6]. On the other hand the HbA[1]C in patient with SS disease and G6PD deficiency was 6.9 +/- 1.08% which is statistically different from patient with SS disease and normal G6PD status [5.6 +/- 1.08%] [P value < 0.04]. G6PD deficiency may be beneficial in reducing the haemolytic crises in Saudi paediatric SS patient