Determination of loratadine and its tablets by H1 NMR spectrometry

ABSTRACT

A new method, involving the application of 1H-NMR spectrometry for the assay of loratadine and its tablets, is proposed. The 1H-NMR spectrum of loratadine in DMSO [d6] has a well-defined triplet [around delta 1.3 ppm] and a quartet [near delta 4.3 ppm] which are chosen for quantitative analysis. The method is based on comparing the integral of these signals to that of the sharp singlet of maleic acid at delta 6.5 ppm which is used as internal standard. The proposed method is simple and rapid, giving accurate and reproducible results when applied for the analysis of both authentic loratadine and its tablets. In addition, the 1H-NMR spectrum obtained helps in confirming the identity and purity of the drug