Synthesis and reactions of B-ketoanilides for biological evaluation

ABSTRACT

2-Arylidene cycloalkanones react with acetocetanilide to give the corresponding B-ketoanilides Ia-f which react with hydroxyl-amine and/or hydrazine hydrate in acetic acid to give respectively compounds III and compounds V. Compounds I also react with o-phenylene diamine and/or diethyl malonatethiourea to produce respectively compounds VI and compounds VIII. Chemical screening for the products are mentioned