Synthesis of some new benzimidazole derivatives as antimicrobial agents

ABSTRACT

Synthesis of 2-[p-4-aryl-3-cyano-2-oxo[IH] pyridin-6-yl] anilino] benzimidazoles [2a-g] and the 2-[p-[4-aryl-3-cyano-2-imino[IH] pyridin-6-yl] anilino] benzimidazoles [3a-g] were obtained in one step reaction between the 2-[p-acetylanilino] benzimidazole [1] with ethyl cyanoacetate and/or malononitrile and the appropriate aldehydes in the presence of ammonium acetate. The new compounds showed considerable antimicrobial activity against Gram +ve, Gram -ve bacteria, yeast and fungi