Synthesis of some cytidine derivatives

ABSTRACT

Synthesis of some cytidine derivatives involving 4,5 cyclisation are performed by the individual reactions of both of 5-hydroxy, 5-mercapto and 5-amino cytidines with chloroethyl formate, thionyl chloride and thiophosgene successively. On the other hand, reactions of cytidine with chloroacetone or chloropropionaldehyde give 3,4-cyclized cytidine products