Cireulating intercellular adhesion molecule-1 [ICAM-1] rheumatoid arthritis and systemic lupus erythematosus

ABSTRACT

Circulating intercellular adhesion molecule-1 [C. ICAM-1] levels were measured by enzymelinked immunosorbent assay for sera collected from 29 patients with rheumatoid arthritis [RA] and 20 patients with systemic lupus erythematosus [SLE] as well as synovial fluid samples collected from 5 out of the 29 RA patients. Serum samples from 10 healthy persons were tested as a control group. The concentration of C3[c] complement component was also measured in the serum of patients with SLE by single RID technique and compared with its concentration in the control group. There was a significant increase [p<0.05] in the level of CICAM-1 in SLE patients compared with normal controls. In contrast, non significant increase was found in patients with RA. Levels of CICAM-1 was non significantly increased in synovial fluid compared with serum in paired samples from patients with RA. A highly significant increase in C. ICAM-1 levels was found in SLE patients [p<0.01] as compared to RA patients. Level of CICAM-1 correlated significantly with increased erythrocyte sedimentation rate [ESR] and decreased haemoglobin [Hb] level in SLE patients. There was significant positive correlation between C ICAM-1levels and joint score in patients with RA. Highly significant decrease in C3[c] complement component was found in SLE patients as compared to control group, but there was non significant correlation between CICAM-1 levels and C3[c] complement component levels in those patients. From the previous results, it was found that ICAM-1 could be used as a parameter of activity in patients with SLE and to less extent in patients with RA. Non significant difference was found in CICAM-1 levels in synovial fluid versus serum