Assessment of the therapeutic efficacy of praziquantel on the colonic lesion in experimentally infected mice with schistosoma mansoni

ABSTRACT

Therapeutic efficacy of praziquantel on colonic schistosomiasis was assessed in this study. Sixty swiss albino mice were infected by 80-100 Schistosoma mansoni cercariae and classified into four groups these first group received a single oral dose of 6.24 mg praziquantel/mouse, the second group was treated by the same dose daily in two successive days, the third group was treated also by the same dose in three successive days and the fourth group was left untreated as a control group. It was found that the third group which was treated by the triple doses give a higher cure rate [98%] than the other two treated groups [64.7% and 82.7% respectively]. Histopathological examination of the colon showed no definite pathological changes in the third group in comparison with the other groups. These data indicate that treatment by the triple doses of praziquantel on three successive days gives a high cure rate of the patients with less side effects