Effect of schistosoma mansoni infection on kidney sodium potassium adenosine triphosphatase activity in experimental

ABSTRACT

Schistosoma mansoni is a common parasite in Egypt. Disturbance in renal function is a striking complication of bilharzial infection. ATPase enzyme is considered to be responsible for the generation of energy supply for the extrusion of Na[+] exchange for K[+] and maintence of water and electrolyte balance. In this study Na [+] K[+] ATPase activities have been assayed in kindeys of healthy and Schistosoma mansoni - infected mice before and after treatment with praziquantel. Schistosoma mansoni infection caused significant decrease of the kidney Na[+] - K[+] ATPase activities which were reversed by treatment of mice with praziquantel [200 mg/kg B. Wt. for three doses in 24 hours]. Possible explanations of these findings are clarified