Treatment of post transplantation kaposi's sarcoma with interferon

ABSTRACT

Kidney transplanted patients under the immunosuppressive therapy are at risk of acquiring Kaposi's sarcoma [KS]. A 26 years old Somali male patient developed KS [10 months after renal transplantation] whilst on cyclosporin A, azathioprine and prednisolone. The clinical diagnosis of KS was confirmed by the biopsy. There was no lymphadenopathy nor visceral involvement. The patient received recombinant alpha 2a interferon in an subcutaneous injection of 6 million units three times weekly for three months [36 injections]. The KS regressed gradually and disappeared completely with brownish pigmented skin. Now, after more than 20 months, the patient is well with a well functioning graft and there is no recurrence of the KS inspite of the patient is still on the same immunosuppressive therapy