Prophylactic action of testosterone on lipid metabolism of liver and serum in gamma irradiated albino rats

ABSTRACT

The present study has been carried out to investigate the efficiency of testosterone as a radioprotector agent. The levels of total lipids and triglycerides as well as the lipolytic activity of liver and serum in gamma irradiated rats were selected for this study at periods of 1, 3, 7, 10 and 14 days post irradiation.The results indicated that whole body gamma irradiation at the dose of 7 Gy caused different significant changes in the levels of total lipids and triglycerides of the liver. However an evident elevation in serum total lipids and triglyceride contents produced at all post irradiation days. The enzymatic activity of serum and liver lipase significantly increased on the 3rd and 7th days post-irradiation and decreased at the other experimental times. Pre-treatment of rats with testosterone, 10 days, before whole body gamma irradiation [7 Gy] has minimized the variation occurred in the levels of the studied parameters in both liver and serum