Triple therapy in duodenal ulcer healing: a follow-up study

ABSTRACT

Thirty nine Helicobacter pylori [HP] positive chronic duodenal ulcer patients completed the 4 weeks treatment of triple therapy [Denol, Metronidazole and Amoxil]. Of these 29 showed healed duodenal ulcer and negative CLO test at 8 weeks [eradication]. They were followed at 3.6 and 12 months and at each follow-up, endoscopy and CLO testing were repeated. At 12 weeks, 54% showed a healed ulcer and negative CLO and these figures reached to 69 and 66% at 6 and 12 months respectively. Thirty percent relapsed within 1 year. The present study indicates a prolonged remission of duodenal ulcer following HP eradication