Blood picture of albino rats experimentally injected with prostaglandin F2 alpha [PCG2a]

ABSTRACT

Three hundreds mature male albino rats were used in this study. They were divided into 6 groups each of 50 the first group was kept as control and injected with 0.2 ml of saline daily. The second, third, fourth, fifth and sixth were injected with PGF[2] alpha in doses of 10, 20, 50, 75 and 125 ug respectively. The control and treated groups were injected subcutaneously for 7 days. At each chosen different intervals viz.1, 7, 14, 21, 28, 35, 42, 49, 56, and 70 days from the last injection, five rats from each group were randomly taken and subjected to haematological examination. The result obtained were as follows a significant increased in blood haemoglobin and red blood corpuscles was seen in rats obtaining low doses of PGF[2] alpha. Rats receiving the high doses of the drug, there was a significant decrease in heamoglobin, red blood corpuscles and packed cell volume. Leucocytosis and lymphocytopenia was observed in all rats. Inhibitory effect of platelets in rats with low doses and stimulatory effect in groups with the high doses