Comparative toxicological interaction study of clonidine and clomipramine in albino rats

ABSTRACT

The present work was deigned to study some of the side effects of one ofcentrally acting antihypertensives [clonidine] and one of the tricyclicantidepressants [clomipramine] and evaluate the interaction between them,particularly on the liver, kidneys and cardiovascular system for 60 days. 192adult rats of both sexes were used and divided into four equal groups [control[GI], clonidine [G2], clomipramine [G3] and clonidine and clomipramine [G4]]. Several blood samples from animals sacrificed at successive 2 weeks interval were taken for the quantitative determination of alanine amino transferase [ALT] and aspartate amino transferase [AST], reflecting any disturbance in the liverfunction. Kidney functions were also determine by the estimation of bloodurea and serum creatinine. In addition, blood pressure rate and ECGestimation were done at the same intervals. It could be concluded that therapy with clonidine and clomipramine should be controlled by regular assessment of the liver and renal function tests. Also, ECG was recommended for following up the long-term therapy. This study also recommended to avoid their combination in hypertensive patients with depression