Effect of ketamine and propofol on blood coagulation in dogs [a comparative study]

ABSTRACT

This study was carried out on 20 dogs of mixed breed and of both sexes weighting 12 - 16 kg. The animals were divided into 2 groups with 10 dogs in each group. Group I received 5.5 mg/kg ketamine. Supplementary doses of 3 mg/kg were given IV at intervals of 30 minutes. Group II received propofol in a dose of 2.5 mg/kg during induction followed by 0.3 mg/kg/min. infusion. Both groups were premedicated by atropine sulfate and diazepam. Heart rate, respiratory rate and temperature were measured before anesthesia and at 15-minute intervals for one hour then 30-minute intervals for another hour following induction of anesthesia. Blood samples for coagulation profile [PT, APTT, fibrinogen concentration and platelet count] were extracted before anesthesia and at the same timing of vital signs recording following induction of anesthesia. It was concluded that propofol and ketamine do not alter blood coagulation