study on the effect of some anti-oxidants and angiotensin in converting enzyme inhibitors on some renal functions and predicative changes in glycerol-induced acute renal failure in the rat

ABSTRACT

The present work was designed to evaluate the effects of some antioxidants; vitamin E, vitamin C, deferoxamine and the ACE inhibitors [captopril and enalapril] on renal functions and peroxidative changes in glycerol-induced ARF in the rat. Drugs were given before and after induction of ARF by im injection of hypertonic glycerol solution. Serum and urinary urea, creatinine concentrations, urinary/serum urea and creatinine ratios, creatinine clearance, serum malondialdehyde as well as renal reduced glutathione concentrations were estimated. All the above mentioned drugs showed a significant renoprotective effect by improving the marked deterioration of the estimated kidney function tests in the uremic rats