effect of ivermectin on trichinella spiralis in mice

ABSTRACT

The effect of ivermectin on Trichinella spiralis was studied in Swiss albino mice. The drug was given in 3 different doses [200 mug, 500 mug and 1 mg/kg] in the early intestinal, preencystment and late encystment stages. The drug was effective against the adult worms giving cure rates of 80.2% when given in the low dose up to 89.7% when given in the high dose, with a subsequent reduction in the muscle larval count by 78.8% to 93.3%. The drug was moderately effective against the early muscle larval stages where it produced a reduction in the muscle larval count between 35% and 71.2% when applied in the preencystment stage. In the late encystment stage, the drug was poorly effective against the encysted larvae, reducing their number by 16.4% to 40.6% in comparison with the control. The histopathological findings confirmed the results in terms of the density of muscle larvae and the degree of inflammatory cellular reaction around