Hepatic changes in experimental trichilemma spiralis infection

ABSTRACT

Histopathological and immunofluorescent studies were carried out on the liver in rats experimentally infected with Trichinella spiralis throughout 24 weeks after infection. Definite histopathological changes were found in the liver of infected animals from the early weeks after infection in comparison with the control animals. The deposition of specific antigens and immune complexes was demonstrated in the infected animal liver by means of direct and indirect immunofluorescence. Few larvae were detected in the liver of infected animals. The findings were discussed and the role of immune complex deposition in the pathogenesis of the hepatic lesions was declared