role of monoamines in the regulation of pituitary gonadotropins in normal and castrated rats

ABSTRACT

Despite suggestion of multiplicity of neurotransmitters and neuromodulators contributing in the regulation of pituitary gonadotropins secretion the picture regarding catecholamines in intact and castrated rats is not clear. This study deals with the differential response of pituitary FSH and LH to immediate effect of different adrenergic and non - adrenergic agonist/antagonist [adrenaline, noradrenaline, proparnolol, isoprenaline, clonidine, phenoxybanzamine HCI] in the short -term castrated rat model. The evidence is presented for a direct excitatory or facilitatory effect of adrenaline and noradrenaline for pituitary LH regulation viz - a viz testosteron feed back mechanism in castrated rats