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Warfarin resistance in a patient with prosthetic valve endocarditis treated with cloxacillin
SPJ-Saudi Pharmaceutical Journal. 1996; 4 (1): 56-59
en Inglés | IMEMR | ID: emr-43492
ABSTRACT
Systemic anticoagulation with warfarin is the mainstay therapy for patients with valve prosthesis. Such drug therapy is of crucial importance in patients with prosthetic valve endocarditis [PVE] because of higher incidence of thrombo-embolism. We are reporting a case of PYE where the patient developed warfarin resistance due to Cloxacillin administration in spite of concomitant administration of I.V. Heparin. Warfarin dose was increased from a baseline of 5 mg daily before Cloxacillin was started to 30 mg daily during Cloxacillin treatment. Six weeks after completion and discontinuing the antibiotic course, the patient's International Normalized ratio [INR] value gradually increased and Warfarin dose was tapered down over eight days. Cloxacillin-Warfarin interaction seems to be due to rapid metabolism in susceptible subjects leading to a reduction in the hypoprothombinemic effect of warfarin. Our finding is consistent with the reported cases which documented such interaction with other members of Penicillinase-resistant Penicillins such as NafcilIin and Dicloxacillin
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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Warfarina / Resistencia a Medicamentos / Prótesis Valvulares Cardíacas / Cloxacilina / Interacciones Farmacológicas Tipo de estudio: Informe de Casos Límite: Femenino / Humanos Idioma: Inglés Revista: Saudi Pharm. J. Año: 1996

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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Warfarina / Resistencia a Medicamentos / Prótesis Valvulares Cardíacas / Cloxacilina / Interacciones Farmacológicas Tipo de estudio: Informe de Casos Límite: Femenino / Humanos Idioma: Inglés Revista: Saudi Pharm. J. Año: 1996