Biochemical and cytogenetic effects of dichlorvos and sodium dihydrogen phosphate on biomphalaria alexandrina snails specific intermediate hosts for schistosoma mansoni

ABSTRACT

The present work aimed to investigate the chromosomal pattern of Biomphalaria alexandrina snails and the effect of certain chemical compounds such as dichlorvos [DDVP] and sodium dihydrogen phosphate [NaH2PO4] on the chromosomal aberrations beside some biochemical pattern in these snails as intermediate hosts. This was useful in breaking the host parasite relationship, which is very specific and dependable on genetic [chromosomal] status of these hosts. The study showed that both DDVP and NaH2PO4 caused a significant increase in the chromosomal aberrations during the first three days of treatment, while after nine days of treatment, the values were returned to the normal values. The results of DNA, RNA, total protein, amino acids and fatty acids in the tissue of B. alexandrina snails showed varying differences in the different treated groups. Also, the results revealed that both DDVP and NaH2PO4 affected the egg-laying of snails and the susceptibility of the pretreated snails to parasite infection