Effect acute administration of fish oil [omega-3 fatty acids] on aspirin-induced gastric ulcers in rats

ABSTRACT

Fish oils are eicosapentenoic acid [EPA]-rich oils. In the present study, fish oils were investigated for their possible ability to protect the gastric mucosa against the well known aspirin- induced gastric ulceration. The results showed that fish oil [95% EPA] at a dose of 1 or 2 ml/kg body weight provided a significant protection in such conditions. These findings showed that fish oils, rich in eicosapentenoic acid [EPA], have a significant antiulcerogenic effect