Growth in children with chronic renal failure and after transplantation

ABSTRACT

The aim of this work was to study the relation between height expressed as st and ard deviation scores [HtSDS] for chronological age, glomerular filtration rate [GFR] and hormonal alteration in children with chronic renal failure [CRF] on regular hemodialysis [HD] and the possible role of normal graft function after kidney transplantation in this respect. The study comprised 18 children with a mean age of 10.56 +/- 3.08 year and 16 children with normal graft function [mean age 11.06 + 3.19]. The mean duration on HD was 14.72 +/- 7.73 month for CRF group and the mean interval after transplantation was 1.97 +/- 0.9 year for the group of functioning grafts. Ten normal healthy children of matched age and sex served as controls. All patients were subjected to careful history taking, full clinical examination, assessment of growth parameters, laboratory investigation including serum growth hormone [hGH] and serum parathormone [PTH] measured by radioimmunoassay. Growth performance was evaluated twice at the beginning of the study and after a period of one year