Some hematological features of lead - intoxication

ABSTRACT

The goal of this study is to demonstrate the effect of exposure to lead on some hematological parameters. The study was carried out on twenty male rats exposed to different doses of lead acetate [one and two mg/kg body weight respectively]. Blood samples were taken after intraperitoneal injection for one week [acute effect] and eight weeks [chronic effect]. With low dose and after one week exposure statistically significant elevation were encountered with respect to blood lead level, Hb A[2]% and Hb F%. After eight weeks exposure significant reduction of erythrocyte count, hemoglobin concentration, erythrocyte delta amino-levulinic dehydratase and pyrimidine -5-nucleotidase were detected, with significant elevation of erythrocyte zinc protoporphyrin. Rats exposed to higher dose had obvious significant effect on the above mentioned parameters specially after prolonged exposure, with significant increase of Hb A[2]%