Effect of ivermectin on experimental trichinosis

ABSTRACT

This work was carried out to assess its effect against T. spiralis infection in Swiss albino mice as a single dose treatment. Ivermectin was administered to infected mice one day before, the same day, 5, 10 and 35 days post Trichinella infection. Assessment of the drug effect was done through a parasitological study, which included adult count, larval count, measurements of the length of the adult females, larvae and the reproductive capacity index as well as scanning electron microscopic study of the adult and larva. The results showed that the administration of ivermectin on the same day of infection was most effective and its effect diminished progressively