Serum proteins and triglycerides after oxamniquine administration in normal and schistosomal infected mice

ABSTRACT

The effect of oxamniquine on serum proteins and triglycerides was studied in mice. A single oral dose of oxamniquine [50 mg/kg b.w.] was administered after three months from the schistosomal infection. The same dose was given also to normal control group of animals. Blood samples were withdrawn prior to drug administration and periodically every two weeks for two months. It was concluded that oxamniquine caused an elevation on serum alpha1, alpha2 beta and total globulins in normal mice. In schistosomal infected mice, oxamniquine administration inhibited the abnormalities in A/G ratio and significantly decreased triglycerides