effect of albendazole and mebendazole on echinococcus granulosus protoscolicies

ABSTRACT

This study was carried on to show the effect of albendazole and mebendazole and their combination on the survival of protoscolices of Echinococcus granulosus in mice. In vitro, a concentration of 10 mg/ml of albendazole and mebendazole and their combination reduced the survival of protoscolices, but on the first three days the effect of combination of drugs and mebendazole alone were greater than albendazole. In vivo, intraperitoneal administration of albendazole and mebendazole and their combination reduced the number and size of hydatid cyst in mice one month post infection, but did not prevent the development of cysts. The effects of combination of drugs were greater on both number and size of cysts than using albendazole or mebendazole alone