Does low dose of suxamethonium with propofol induction provide adequate intubation condition and prevent post-operative myalgia?

ABSTRACT

The present study has demonstrated that the incidence of myalgia and fasciculations has decreased significantly in patients given low dose suxamethonium [0.25 mg/kg] with propofol than the average dose [1 mg/kg] used with thiopentone and a similar degree of clinical neuromuscular block with no difference in the intubating conditions was achieved in both groups. The concentration of creatine kinase increased in both groups, but the increase was significantly higher with larger dose of suxamethonium. So, the findings support that there is a good subjective correlation between muscle pain and biochemical indices of muscle damage