Influence of schistosomiasis on testicular endocrine function and testosterone metabolism

ABSTRACT

The study included 17 male patients with schistosomal hepatic fibrosis and 14 normal controls. They were investigated for evidence of altered androgen secretion and metabolism. The endocrine testicular function was evaluated by measuring plasma testosterone [T], free testosterone [FT], dihydrotestosterone [DHT], dehydroepiandrosterone sulfate [DHEAS], androstenedione [delta 4], testosterone binding capacity and gonadotropins [FSH and LH] levels in patients and controls by radioimmunoassay and immuno-radiometric techniques. Plasma androgens were assessed following IM injection of testosterone enanthate to investigate any altered testosterone metabolism in schistosomal patients. Also, human chorionic gonadotropin [HCG] stimulation was done to evaluate secretory functions of Leydig cells