Glycosylated proteins in vitreous versus blood as a post-mortem diagnostic measure for diabetes mellitus

ABSTRACT

The present study was carried out on 79 Egyptian cadavers, aged 14-75 years. They were classified into two groups Group I [n = 49] included cadavers withnegative history of diabetes mellitus, and group II [n = 30] included cadaverswith positive history of diabetes mellitus. Randomly collected blood samplesas well as vitreous samples from both eyes of cadavers were used and laboratory investigations were performed. The data ultimately obtained were analyzed statistically to be used as a simple model system for postmortem diagnosis of diabetes mellitus. It was concluded that the F/A as well as F/P ratios from the vitreous were considered to be better parameters that fructosamine and/or glucose in the postmortem diagnosis of diabetes mellitus. They were less expensive and less time-consuming than detecting fructosamine and/or glucose in serum, which need correction due to hemolysis- induced interferences. Moreover, the vitreous fluid being well isolated, sterile and devoid of blood was much more better than blood in the postmortem diagnosis of diabetes mellitus