Cisplatin induced toxicity and the modulating effect of antioxidants

ABSTRACT

This study was conducted on 120 albino rats divided into 8 equal groups. The study showed that group V [cisplatin group] caused highly significant increases in blood urea nitrogen [BUN], serum creatinine, total cholesterol, triglycerides, total bilirubin, direct bilirubin, alkaline phosphatase, serum glutamic pyruvic transaminase [SGPT], serum glutamic oxaloacetic transaminase [SGOT] together with highly significant reductions in serum electrolytes [serum calcium, Ca, serum potassium, K and serum sodium, Na], total proteins and albumin. Histopathological examination of kidney in group V showed tubular necrosis, focal cytoplasmic vacuolation and interstitial hemorrhages. Histopathological examination of liver in group V showed cloudy swelling of hepatocyte and sinusoidal dilatation