protective role of nifedipine and vitamine C om bromobenzene hepatorenal toxicity

ABSTRACT

In this study the hepatorenal protective effects of nifedipine and vitamin C were investigated in albino rats during acute and chronic bromobenzene [Br B] induced hepatorenal toxicity. Hepatotoxicity and hepatoprotective activities were monitored by estimating serum transaminase [SGPT and SGOT], alkaline phosphatase [ALP], total bilirubin [TB] and total proteins [TP]. Nephrotoxicity and nephroprotective activities were monitored by estimating blood urea nitrogen [BUN] and serum creatinine. Histopathological and histochemical studies of the livers and kidneys of experimental rats were also done. Administration of nifedipine and vitamin C concomitant with Br B to rats led to complete normalization of toxin induced alteration assessed by biochemical parameters and almost abolishing the toxin induced histopathological and histochemical changes in the rats livers and kidneys. A conclusion was made that infedipine and vitamin C have protected against bromobenzene induced hepatorenal toxicity