Studies of some enzymatic and protein fractions in some renal disorders II Nephrotic syndrome

ABSTRACT

The study included 20 children with nephrotic syndrome, their age ranged from 2-12 years, of both sexes10 normal children of matched age six with the diseased children and form the same socioeconomic standard were chosen. For each of the patients, the following investigations were done 1- Determination of urinary proteins. 2- Determination of creatinine level both in urine and serum. 3- Detemination of the activities of the following enzymes both in urine and serum. A] Lactate dehydrogenase [LDH]. b] alkaline phosphate enzyme [ALp]. c] Gamma-Glutamyl transferees [Gamma-GT]. The results showed that the concentration of the studied urinary proteins were found significantly higher in nephrotic group compared to normal. The difference in the molecular weight of these proteins contributed to the difference in their relative concentration in urine. In more severe renal affection, where the glomerular permeability in markedly increased proteins of higher molecular weight such as IgA appear in urine. A significant higher values of creatinine both in serum, urine its clearance in nephrotic group compared to normal is observed